Volumetric Liquid Filling Machine - Syringe Dosing

Description & Operating Principle

HMEC’s Volumetric Syringe Liquid Filling Machines operate on a mechanical positive displacement principle using precision-bored stainless steel SS 316L or borosilicate glass syringe assemblies. During the intake stroke, a high-precision rotary rotary valve or non-return ball valve draws an exact volume of liquid from the product buffer tank into the syringe barrel. On the discharge stroke, the synchronized plunger pushes the measured liquid through diving nozzles into the containers.

Driven by variable speed motors or advanced servo drives, HMEC volumetric fillers ensure consistent stroke depth and controlled filling velocity, preventing foaming, aeration, or splashing even with delicate or carbonated pharmaceutical formulations.

Target Products & Applications

Volumetric syringe fillers are the industry standard for pharmaceutical liquid formulations, liquid oral dosage forms, and cosmetic bottling:

💊 Pharmaceutical Syrups & Suspensions

Cough syrups, oral antibiotic suspensions, liquid antacids, paracetamol syrups, and tonics.

🧪 Oral Drops & Health Supplements

Pediatric vitamin drops, herbal extracts, nutraceutical liquids, and liquid oral tinctures.

🧴 Cosmetics & Personal Care

Face serums, toners, hair oils, micellar water, liquid hand soaps, and sanitizers.

🍶 Food & Specialty Flavors

Food essences, liquid vanilla extracts, vinegar, aromatic oils, and food coloring syrups.

Pros & Cons Comparison

✅ Advantages (Pros)

High Repeatable Accuracy: Precision volumetric syringes guarantee ±0.5% to ±1% dose accuracy.
Proven cGMP Reliability: 40+ years of proven pharmaceutical track record in FDA/WHO-GMP certified plants.
Cost-Effective Capital Investment: Lower upfront cost compared to multi-sensor flowmeter systems.
Handles Foaming Liquids: Synchronized bottom-up diving nozzles eliminate air entrapment and foaming.
Self-Priming Operation: Syringe suction easily draws liquids from floor-level or overhead vessels.

⚠️ Considerations & Limitations (Cons)

Syringe Changeovers Needed: Large volume jumps (e.g. 30ml to 1000ml) require swapping syringe barrel sets.
Mechanical Wear Parts: Piston seals and O-rings require periodic inspection and replacement.
Manual Stripping for Deep Clean: Requires manual dismantling or dedicated CIP manifolds for cross-batch cleaning.
Particulate Limitation: Abrasive solid chunks or large particulates can score precision syringe walls.

Type & Range of Volumetric Syringe Machines

On basis of automation & heads

✅ Semi-Automatic Single / Twin Syringe Filler
✅ 2 Head Automatic Volumetric Liquid Filler
✅ 4 Head Automatic Volumetric Liquid Filler
✅ 6 Head Automatic Volumetric Liquid Filler
✅ 8 Head High Speed Volumetric Liquid Filler
✅ 12 Head High-Speed Rotary Volumetric Filler

On basis of drive mechanism

✅ Mechanical Cam / Crank Drive with VFD
✅ Servo Motor Controlled Stroke Drive
✅ Pneumatically Actuated Syringe Plungers

On basis of features

✅ With Automatic Rejection System
✅ With Bottom-up Diving Nozzles (Anti-Foam)
✅ With "No Bottle - No Fill" Safety Sensors
✅ With Suck-Back Anti-Drip Nozzles
✅ With Safety Acrylic / Polycarbonate Enclosure

All product contact parts fabricated from high-grade SS 316 / SS 316L
Precision-honed volumetric syringes ensure repeatable dosing within ±0.5%
Synchronized diving nozzles submerge during filling and rise smoothly with fluid level
Positive suck-back shut-off valve prevents tailing and post-fill nozzle dripping
"No Bottle - No Fill" optical sensor prevents spillage and line contamination
Quick tool-less volume adjustment with calibrated scale indicator
Integrated automatic checkweigher and pneumatic bottle rejection mechanism
Robust heavy-duty structure clad in aesthetic AISI 304 stainless steel

Output / Speed	20 to 200+ Bottles Per Minute (BPM) depending on heads and fluid viscosity
Dosing Range	5 ml to 1000 ml (With interchangeable syringe sets: 5-30ml, 30-100ml, 100-500ml, 500-1000ml)
Dosing Accuracy	± 0.5% to ± 1.0% (Formulation dependent)
Number of Syringes / Heads	Single, 2, 4, 6, 8, 12 Heads (Linear & Rotary Formats)
Syringe Material	Stainless Steel AISI 316L / Borosilicate Glass
Material of Construction	AISI 316L (Contact Parts), AISI 304 (Frame and Cabinet)
Control Architecture	PLC with Touchscreen HMI and Variable Frequency Drive (VFD)
Rejection Mechanism	Pneumatic Bottle Pusher / Diverter with Reject Tray
Electrical Power	415V / 3 Phase / 50Hz (Customizable for 110V/220V global power supply)
Pneumatic Supply	5 to 6 Bar Clean Compressed Air

To switch between different bottle sizes and fill volume brackets, the following change parts are available:

Interchangeable SS 316L Syringe & Piston Sets
Liquid Intake & Discharge Non-Return Valve Blocks
Diving Nozzles with Anti-Drip Tips
Container Bottle Guide Rails & Stopper Gates
Infeed / Outfeed Star Wheels & Worm Screws
Silicone / PTFE Sanitary Food-Grade Gasket Kits

How does the diving nozzle prevent foaming in syrups?

The diving nozzle plunges deep to the bottom of the empty bottle before liquid release begins. As fluid fills the container, the nozzle smoothly rises just above the liquid level, preventing turbulence, bubbles, and foaming.

What syringe sizes are available for volume changeover?

We offer modular syringe barrels ranging from 5ml-30ml, 30ml-100ml, 100ml-500ml, and 500ml-1000ml. Fine adjustments within each syringe's span are made via the micrometer adjustment scale.

Can this machine handle hot liquids or suspensions?

Yes, our SS 316L syringe blocks withstand hot filling up to 85°C. For oral suspensions with settled particles, an optional jacketed buffer tank with a slow-speed agitator ensures uniform suspension during dosing.

Does the machine comply with cGMP pharma validation standards?

Yes, HMEC machines are engineered to strict cGMP guidelines with full material traceability (MTC), sanitary welding, and complete DQ, IQ, and OQ validation protocol documentation.

Volumetric Syringe Liquid Filling Machine